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KMID : 0613820070170101387
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Journal of Life Science
2007 Volume.17 No. 10 p.1387 ~ p.1393
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Effects of Hambag Mushroom (Grifola frondosa)-Powder on Hyperglycemia and Hyperlipemia in STZ and High Fat Diet-induced Diabetic Rats
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Park Yeong-Chul
Kim Jong-Bong
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Abstract
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Hambag mushroom is edible mushroom, and one of new strains in Grifola frondosa. It was developed from Korean wild Grifola frondosa by National Institute Science & Technology. In this study, we investigated the effects of the powder extracted from fruit-body of hambag mushroom on hyperglycemia, hyperlipemia and pancreatic cells in rats with streptozotocin (STZ) and high fat diet-induced diabetes. The diabetic rats were fed with hambag mushroom-powder (1 and 2% of diet weight) for 6 weeks. And then the levels of blood glucose and lipid and the pancreatic tissue were analyzed and compared. The diabetic rats fed with hambag mushroom-powder lost less body weight than those fed with the powder-free normal diet. Blood glucose levels in the diabetic rats fed with hambag mushroom-powder at all concentrations was lower by 50% than in the diabetic rats fed with normal diet. The levels of total cholesterol, triglyceride and LDL-cholesterol in the diabetic rats fed with hambag mushroom-powder were increased compared to those in the diabetic rats fed with normal diet. There were the blood levels of cholesterol, triglyceride and LDL-cholesterol by hambag mushroom-powder concentrations in a dose-dependent response. The decreased damage of pancreatic tissue in the group treated with hambag mushroom-powder could be suggested possibly as one of mechanisms for the effects of hambag mushroom-powder on hyperglycemia and hyperlipemia.
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KEYWORD
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Hambag mushroom(Grifola frondosa), STZ-induced diabetic rats, hyperglycemia, hyperlipemia
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